Tablet rigar granulation tsari

Allunan a halin yanzu suna ɗaya daga cikin nau'ikan nau'ikan allurai da aka fi amfani da su, tare da mafi girma da fitarwa kuma mafi yawan amfani da su.Tsarin rigar granulation na gargajiya har yanzu shine babban tsari a cikin samar da magunguna.Yana da balagagge samar matakai, mai kyau barbashi ingancin, high samar yadda ya dace, da kuma matsawa gyare-gyare.Kyakkyawan da sauran fa'idodi, shine mafi yawan amfani da shi a cikin masana'antar harhada magunguna.

The masana'antu tsari na Allunan za a iya kullum za a raba zuwa aiki na raw da kuma karin kayan, yin la'akari, granulating, bushewa, hadawa, tableting, shafi, da dai sauransu Akwai wata magana a cikin masana'antu: granulation ne shugaba, tableting ne ainihin. da marufi ne Phoenix wutsiya, ana iya ganin cewa granulation tsari taka muhimmiyar rawa a cikin dukan kwamfutar hannu samar, amma yadda za a yi taushi da kuma samun granules, ya zuwa yanzu akwai kawai mai zurfi ma'ana a cikin litattafan "riƙe cikin wani ball, tabawa da tarwatsawa” , Ba a yi cikakken bayani ba.Dangane da kwarewar marubucin a cikin ainihin samarwa, wannan labarin yana nazarin abubuwan gama gari da yawa waɗanda ke shafar tsarin aikin jika na kwamfutar hannu, kuma yana ba da shawarar matakan kulawa masu dacewa don tabbatar da ingancin samar da ƙwayoyi.

Pretreatment na albarkatun kasa

Danye da kayan taimako gabaɗaya suna buƙatar murkushe su kuma a tantance su kafin haɗewar rigar da samar da granulation.Wasu al'amuran da ba su cancanta ba waɗanda galibi ke faruwa a cikin aiwatar da allunan, kamar haɗawa mara daidaituwa, tsagawa, mannewa ko rushewa, da sauransu, suna da alaƙa da ƙarancin ƙwanƙwasa ɗanyen kayan da aka yi a lokacin pretreatment.Idan albarkatun ƙasa sun kasance masu ƙima ko lu'ulu'u masu siffar allura, yuwuwar karkatattun abubuwan da ke sama za su kasance a bayyane.Allon don pretreatment, murkushewa da sieving a cikin gargajiya tsari ne gaba ɗaya 80 raga ko 100 allon raga, amma tare da ci gaban kayan aiki da albarkatun kasa da fasaha, mafi yawan albarkatun da aka murkushe ta hanyar 80 raga allo a cikin gargajiya tsari. yanzu zai iya wuce 100. Yiwuwar abin da ke sama yana raguwa sosai don foda mai kyau wanda aka murƙushe ta hanyar 100-mesh sieve.Sabili da haka, ingancin kayan danye da kayan taimako ta hanyar raƙuman raƙuman raƙuman ruwa 100 yana maye gurbin tsarin sieving na raga 80 a hankali.

Yin awo

Saboda karuwa ko raguwa na nauyin kowane abu zai haifar da canje-canje masu zuwa a cikin wasu yanayi na tsari, wanda zai haifar da rashin zaman lafiyar ƙwayar ƙwayar cuta, wanda zai iya haifar da jerin matsaloli irin su guntuwar kwamfutar hannu, friability mai wuce kima, jinkirin rushewa ko ragewa. rushewa, don haka duk lokacin da kuka ciyar Ba za a iya daidaita adadin ba bisa ga ka'ida ba.A cikin yanayi na musamman, ya kamata a tabbatar da nauyin nauyi bisa ga tabbatarwar tsari.

Shiri na barbashi
A zamanin yau, babban-gudun rigar hadawa granulator shine kayan aikin da aka fi amfani da su wajen samar da granulation.Idan aka kwatanta da mahaɗar gargajiya da granulator, irin wannan nau'in granulator a zahiri ya kasance saboda matsalar takardar sayan magani iri-iri ko kuma neman babban inganci.Sabili da haka, ba a kawar da granulator ba, kuma ana amfani da granulator mai girma mai sauri a matsayin mahaɗin gargajiya kawai, sa'an nan kuma ana samun ƙarin nau'in granules ta hanyar granulation.Yanayin tsari wanda ke shafar ingancin jik ɗin granules galibi sun haɗa da abubuwa da yawa kamar zafin jiki, sashi, ƙara hanyar ɗaure, motsawa da yanke saurin granulator, da motsawa da yanke lokacin.

Zazzabi na m
Zazzabi na manne shine mafi wuyar ma'aunin ma'auni don sarrafawa a cikin samar da sikelin.Yana da kusan ba zai yiwu ba don sarrafa daidaiton zafin jiki daidai kafin ƙara m kowane lokaci.Sabili da haka, yawancin nau'in ba za su yi amfani da zafin jiki a matsayin ma'aunin sarrafawa ba, amma a cikin ainihin samarwa, an gano cewa zafin jiki na sitaci yana da tasiri mafi girma a kan wasu nau'i na musamman.Don waɗannan nau'ikan, ana buƙatar zafin jiki a sarari.A ƙarƙashin yanayi na al'ada, zafin jiki ya fi girma.Mafi girma da ƙananan mannewa, ƙananan friability na kwamfutar hannu;mafi girma da sitaci slurry zafin jiki, ƙananan mannewa, kuma mafi girma narkar da kwamfutar hannu.Saboda haka, a wasu matakai da ke amfani da sitaci slurry a matsayin mai ɗaure, ya kamata a sarrafa yanayin zafin mai ɗaure zuwa wani ɗan lokaci.

Yawan m

Adadin mai ɗaure yana da tasirin da ya fi dacewa a kan ɓangarorin rigar, don haka adadinsa kuma ana amfani dashi azaman ma'aunin sarrafawa mai mahimmanci.Gabaɗaya, mafi girman adadin abin ɗaure, mafi girman ƙarancin barbashi da taurin, amma adadin mai ɗaure sau da yawa yakan bambanta da nau'in kayan ɗanye da kayan taimako.Haka kuma za a samu ‘yan sauye-sauye a cikin bambance-bambancen da ke tsakanin nau’o’in iri daban-daban, wadanda ke bukatar a tara su a cikin tsarin samar da dogon lokaci bisa ga nau’o’in iri daban-daban.Don daidaita ma'auni na kayan laushi, a cikin ma'auni mai ma'ana, hanyar da za a kara yawan abin da aka yi amfani da shi ya fi kyau fiye da hanyar ƙara lokacin haɗuwa.

Mahimmanci na m

Gabaɗaya, mafi girman ƙaddamarwar mannewa, mafi girman danko, wanda ba zai iya rabuwa da adadin sa.Yawancin masana'antun ba za su zaɓa don daidaita ƙaddamarwa ba lokacin da suke samun ƙaddamarwar mannewa bayan tabbatarwa, amma sarrafa kayan abu mai laushi ta hanyar daidaita yawan adadin manne, yawanci haɗin gwiwa Za a rubuta ƙaddamar da wakili a matsayin ƙayyadadden ƙima a cikin ƙayyadaddun tsari kuma zai ba za a yi amfani da su daidaita ingancin jika barbashi, don haka ba zan maimaita a nan.

Yadda ake ƙara m

Yi amfani da injin haɗaɗɗen rigar mai saurin gaske don yin granulu.Gabaɗaya, akwai hanyoyi guda biyu don ƙara abin ɗaure.Daya shine a dakatar da injin, bude murfin granulator, sannan a zuba abin daure kai tsaye.Ta wannan hanyar, da ɗaure ba sauki tarwatsa, da granulation ne Wani lokaci yana da sauki sa high gida taro da m barbashi tightness.Sakamakon shine cewa allunan da aka fitar sun tarwatse ko narkar da babban bambanci;ɗayan kuma shine rashin tsayawa, ta yin amfani da hopper feeding hopper, buɗe bawul ɗin ciyarwa, da motsawa.Ƙara a cikin tsari, wannan hanyar ciyarwa na iya kauce wa rashin daidaituwa na gida kuma ya sa barbashi su zama iri ɗaya.Koyaya, saboda buƙatun nau'in ɗaure, ƙirar kayan aiki ko halayen aiki, da sauransu, yana iyakance amfani da hanyar slurrying na biyu a cikin samarwa.amfani.

Zaɓin saurin hadawa da saurin sarewa

Ƙarfafawar kayan abu mai laushi a lokacin granulation yana da alaƙa kai tsaye zuwa zaɓi na motsawa da sauri na ƙwanƙwasa mai saurin haɗuwa da sauri, wanda ke da tasiri mafi girma akan ingancin pellets, kuma kai tsaye yana rinjayar ingancin allunan extruded.A halin yanzu, injin motsawa na babban jika mai haɗawa granulator yana da gudu biyu da ƙa'idar saurin mitar mai canzawa.An raba saurin gudu biyu zuwa ƙananan gudu da babban gudu.Ikon saurin jujjuya mitar yana amfani da sarrafa saurin hannu, amma sarrafa saurin hannu zai yi tasiri ga barbashi zuwa wani matsayi.Sabili da haka, babban mai haɗawa da sauri tare da ƙa'idodin saurin juyawa gabaɗaya yana saita saurin haɗuwa da lokacin gudu, kuma yana fara shirin aiki ta atomatik don rage bambancin ɗan adam.Ga nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan mitar a zahiri ana amfani da su azaman mai sauri biyu, amma ga wasu nau'ikan na musamman, waɗanda ke gudana lokaci guda, zaku iya ƙara saurin samun matsakaicin abu mai laushi, don guje wa haɗuwa na dogon lokaci wanda ya haifar da su. abu mai laushi yayi yawa sosai.

Zaɓin haɗuwa da lokacin shredding

Tsarin tsari wanda ke shafar ingancin kayan laushi shine lokacin haɗuwa da shredding.Saitin sigoginsa kai tsaye yana ƙayyade nasara ko gazawar tsarin granulation.Ko da yake ana iya daidaita saurin haɗuwa da saurin shredding ta hanyar juyawa mita, yawancin zaɓuɓɓukan tsari suna gyarawa don rage bambanci, don samun kayan da ya fi dacewa da taushi, zaɓi don samun kayan laushi masu dacewa ta hanyar daidaitawa lokaci.A ƙarƙashin yanayi na al'ada, ɗan gajeren lokacin haɗawa da shredding zai rage yawa, taurin, da daidaito na barbashi, da tsagewa da rashin cancantar daidaituwa yayin kwamfutar hannu;tsayi da yawa da haɗuwa da shredding lokaci zai haifar da yawa da taurin barbashi Idan an ƙara shi, kayan laushi na iya kasawa yayin damfara kwamfutar hannu, lokacin rarrabuwar kwamfutar zai tsawaita, kuma adadin narkarwar ba zai cancanta ba.

Granulation kayan aiki da granulation dabaru
A halin yanzu, zaɓi na kayan aikin granulating don rigar granulation ya kasu kashi-kashi mai aiki da yawa da granulator mai lilo.Fa'idodin granulator masu aiki da yawa sune babban inganci da sauƙin aiki da amfani.Rashin lahani shine bambancin adadin da saurin ciyarwa saboda ciyarwar da hannu., Daidaitawar kwayoyin halitta ya zama mafi muni;Amfanin nau'in granulator na nau'in lilo shine cewa granules suna da ɗanɗano iri ɗaya, kuma bambancin adadin ciyarwar hannu da saurin ciyarwa kaɗan ne.Rashin hasara shi ne cewa ingancin ya yi ƙasa kuma ana amfani da amfani da allon da za a iya zubarwa don tarwatsawa.Shigarwa ba shi da daɗi.Girman ɓangarorin da bai dace ba zai iya sa bambanci ya wuce iyaka cikin sauƙi.Za'a iya sarrafa lambar raga da saurin dukkan allo don ingantawa.Gabaɗaya, idan ɓangarorin rigar suna da ƙarfi, zaku iya la'akari da haɓaka saurin gudu, zaɓi babban allo, da rage adadin abinci kowane lokaci.Idan ɓangarorin suna kwance, zaku iya la'akari da rage saurin gudu, zaɓi ƙaramin allo, da haɓaka adadin abinci kowane lokaci.Bugu da ƙari, a cikin zaɓin fuska, sau da yawa akan sami bakin karfe da allon nailan don zaɓar daga.Dangane da ƙwarewar samarwa da kayan abu mai laushi, yana da kyau a zaɓi allon ƙarfe na bakin karfe don kayan laushi masu ɗanɗano, da bushe kayan laushi.allon nailan ya fi dacewa, kuma nau'in juyawa na nau'in granulator shima zai iya yin la'akari da tsananin shigarwar allon don daidaitawa don samun ɓangarorin da suka dace. ``

bushewa

Da ilhama yanayin da bushewa sakamako ne barbashi danshi.A barbashi danshi ne mai muhimmanci kimanta factor ga ingancin barbashi.Madaidaicin iko na wannan siga kai tsaye yana shafar bayyanar da friability na kwamfutar hannu yayin ƙaddamarwa.A karkashin yanayi na al'ada, ana iya la'akari da abin da ya faru na chipping a lokacin tableting ko yana haifar da ƙananan danshi, kuma idan mai danko yana faruwa a lokacin da ake yin tableting, dole ne a yi la'akari da ko yana haifar da danshi mai yawa.Ma'anar kula da danshin barbashi gabaɗaya ana ƙaddara ta farko ta hanyar tabbatarwa, amma danshin yana da wuyar haifuwa sau da yawa, kuma yana da mahimmanci don tattara bayanai da tsara kewayon sarrafa danshi.Yawancin hanyoyin bushewa na gargajiya suna amfani da bushewar bushewa.Abubuwan da ke tasiri sun haɗa da sigogi na tsari kamar matsa lamba na tururi, bushewa zafin jiki, lokacin bushewa, da nauyin busassun barbashi.Ana sarrafa danshi na ɓangarorin ta hanyar mai nazarin danshi mai sauri.Kwararren ma'aikaci na iya wucewa na dogon lokaci.A cikin aikin samarwa, ana sarrafa danshi na kowane kayan bushewa a cikin kewayon da ya dace, wanda zai iya inganta ingantaccen samarwa kuma zai iya sarrafa danshi.Baya ga gogewa na dogon lokaci, tushen bayanai na asali da lokacin bushewa da busassun kayan zafi.

Duk granulation na busassun granules

Daidai da rigar granulation shine cewa sigogin tsari waɗanda ke shafar ingancin busassun granules sune gabaɗaya lambar raga da saurin duk allon granulation.Domin tabbatar da santsi samar a lokacin tableting, sami mafi dace barbashi size rarraba.Wannan ita ce dama ta ƙarshe don daidaitawa., Ta hanyar zabar raga daban-daban da kuma saurin juyawa, zai sami tasiri mai mahimmanci akan busassun busassun.Gabaɗaya, lokacin da ɓangarorin sun matse, zaɓi ƙaramin allo, kuma lokacin da barbashi suka saki, zaɓi babban allo.Koyaya, a ƙarƙashin yanayi na al'ada, wannan ba zai zama zaɓi don babban tsari ba.Idan kuna son samun mafi kyawun ƙwayoyin cuta, har yanzu kuna buƙatar yin nazari da haɓaka tsarin shirya kayan laushi.

Hadawa

A hadawa tsari sigogi da shafi barbashi ingancin ne kullum adadin cakuda, gudun da mahautsini, da hadawa lokaci.Adadin cakuda shine ƙayyadadden ƙima bayan an tabbatar da tabbatar da tsari.Gudun mahaɗar na iya yin tasiri ta hanyar juzu'in gudun mahaɗa saboda lalacewa na kayan aiki.Daidaitaccen haɗawa yana buƙatar dubawa tabo na kayan aiki da tabbatar da kayan aiki lokaci-lokaci kafin samarwa.Domin tabbatar da daidaituwar hadawar barbashi zuwa mafi girma da kuma samun samfuran ingancin iri ɗaya, wajibi ne a sami lokacin haɗawa ta hanyar tabbatar da tsari.Isashen lokacin haɗawa shine garanti mai tasiri don tabbatar da matakin watsawar mai mai a cikin busassun busassun, in ba haka ba mai mai zai haifar da ƙungiyoyin tallan na lantarki yayin haɗuwa da busassun busassun, wanda zai shafi ingancin ƙwayoyin.

Sanarwa:
Abin da ke cikin wannan labarin ya fito ne daga hanyar sadarwar kafofin watsa labaru, wanda aka sake bugawa don manufar raba bayanai, kamar abubuwan aiki, batutuwan haƙƙin mallaka, da fatan za a tuntuɓe mu a cikin kwanaki 30, za mu tabbatar da sharewa a karon farko.Abin da ke cikin labarin na marubucin ne, ba ya wakiltar ra'ayinmu, ba shi da wata shawara, kuma wannan magana da ayyukan suna da fassarar ƙarshe.