1. Ana sa ran zai inganta haɗarin kamuwa da cutar koda da kuma mutuwa sakamakon cutar koda.
Ƙungiyar abubuwan da WuXi AppTec ta wallafa a mujallar Medical New Vision ta fitar da wani labari cewa wani bincike da aka gudanar kan mutane 10,000 ya nuna cewa metformin na iya inganta haɗarin kamuwa da cutar koda da kuma mace-mace sakamakon cutar koda.
Wani bincike da aka buga a mujallar American Diabetes Association (ADA) mai suna "Diabetes Care" (Diabetes Care) ya nuna cewa maganin da aka yi da kuma nazarin rayuwa na mutane sama da 10,000 sun nuna cewa marasa lafiya da ke fama da ciwon suga na nau'in 2 da ke fama da ciwon koda na yau da kullun (CKD) da ke shan Metformin yana da alaƙa da raguwar haɗarin mutuwa da kuma cututtukan koda na ƙarshe (ESRD), kuma baya ƙara haɗarin kamuwa da lactic acidosis.
Ciwon koda na yau da kullun matsala ce da ake yawan samu a cikin ciwon suga. Ganin cewa marasa lafiya masu ƙarancin ciwon koda za a iya rubuta musu metformin, ƙungiyar binciken ta binciki marasa lafiya 2704 a cikin kowace ƙungiya biyu da ke shan metformin ba tare da shan metformin ba.
Sakamakon ya nuna cewa idan aka kwatanta da waɗanda ba su sha metformin ba, marasa lafiya da suka sha metformin sun sami raguwar kashi 35% na haɗarin mutuwa sakamakon mutuwa da kuma raguwar kashi 33% na haɗarin ci gaba zuwa cutar koda a matakin ƙarshe. Waɗannan fa'idodin sun bayyana a hankali bayan kimanin shekaru 2.5 na shan metformin.
A cewar rahoton, a cikin 'yan shekarun nan, jagororin Hukumar Abinci da Magunguna ta Amurka (FDA) sun ba da shawarar sassauta amfani da metformin ga marasa lafiya da ke fama da ciwon suga na nau'in 2 da ke fama da ciwon koda na yau da kullun, amma kawai ga marasa lafiya da ke fama da ciwon koda mai sauƙi. Ga marasa lafiya da ke fama da ciwon koda mai matsakaici (mataki na 3B) da kuma mai tsanani, amfani da metformin har yanzu yana da ce-ce-ku-ce.
Dr. Katherine R. Tuttle, farfesa a Jami'ar Washington da ke Amurka, ta yi tsokaci: "Sakamakon binciken yana da kwantar da hankali. Ko da a cikin marasa lafiya da ke fama da cutar koda mai tsanani, haɗarin kamuwa da cutar lactic acidosis yana da ƙasa sosai. Ga marasa lafiya da ke fama da ciwon suga na nau'in 2 da kuma cututtukan koda na yau da kullun, metformin na iya zama ma'aunin rigakafi na mutuwa kuma magani ne mai mahimmanci don gazawar koda, amma tunda wannan bincike ne na baya-bayan nan da kuma lura, dole ne a fassara sakamakon a hankali."
2. Daban-daban hanyoyin magancewa na maganin sihiri na metformin
Za a iya cewa Metformin tsohuwar magani ce ta gargajiya wadda ta daɗe tana aiki. A lokacin da aka fara binciken magungunan rage kiba, a shekarar 1957, masanin kimiyyar Faransa Stern ya buga sakamakon bincikensa kuma ya ƙara ruwan lilac wanda ke da tasirin rage kiba a cikin wake. Alkali, mai suna metformin, Glucophage, wanda ke nufin mai cin sukari.
A shekarar 1994, Hukumar Kula da Lafiya ta Amurka (FDA) ta amince da amfani da metformin a hukumance a cikin ciwon suga na nau'in 2. Metformin, a matsayin maganin da aka amince da shi don maganin ciwon suga na nau'in 2, an jera shi a matsayin magani na farko a cikin jagororin magani daban-daban a gida da waje. Yana da fa'idodin tasirin hypoglycemic daidai, ƙarancin haɗarin hypoglycemia, da ƙarancin farashi. A halin yanzu shine maganin da aka fi amfani da shi a matsayin ɗaya daga cikin nau'ikan magungunan hypoglycemic.
A matsayin magani da aka gwada lokaci-lokaci, an kiyasta cewa akwai masu amfani da metformin sama da miliyan 120 a duk duniya.
Tare da zurfafa bincike, an ci gaba da faɗaɗa ƙarfin maganin metformin. Baya ga sabbin binciken da aka yi, an kuma gano cewa metformin yana da tasirin kusan 20.
1. Tasirin hana tsufa
A halin yanzu, Hukumar Abinci da Magunguna ta Amurka ta amince da gwajin asibiti na "amfani da metformin don yaƙi da tsufa". Dalilin da ya sa masana kimiyya na ƙasashen waje ke amfani da metformin a matsayin maganin hana tsufa na iya zama saboda metformin na iya ƙara yawan ƙwayoyin iskar oxygen da ake saki a cikin ƙwayoyin halitta. Fiye da komai, wannan yana ƙara lafiyar jiki da tsawaita rayuwa.
2. Rage nauyi
Metformin magani ne mai rage kiba wanda zai iya rage kiba. Yana iya ƙara yawan insulin da kuma rage yawan kitse. Ga masu son sukari iri na 2, rage kiba da kansa abu ne da ke taimakawa wajen daidaita sukarin jini.
Wani bincike da ƙungiyar bincike ta Amurka ta yi game da rigakafin ciwon suga (DPP) ya nuna cewa a cikin wani bincike da ba a makance ba na tsawon shekaru 7-8, marasa lafiya da suka sami maganin metformin sun rasa matsakaicin nauyin kilogiram 3.1.
3. Rage haɗarin zubar da ciki da kuma haihuwa da wuri ga wasu mata masu juna biyu
Sabon binciken da aka buga a jaridar The Lancet ya nuna cewa metformin na iya rage haɗarin zubar da ciki da kuma haihuwa kafin lokacin haihuwa ga wasu mata masu juna biyu.
Rahotanni sun ce, masana kimiyya daga Jami'ar Kimiyya da Fasaha ta Norway (NTNU) da Asibitin St. Olavs sun gudanar da wani bincike na tsawon shekaru kusan 20 kuma sun gano cewa marasa lafiya da ke fama da cutar polycystic ovary syndrome da ke shan metformin a ƙarshen watanni 3 na ciki na iya rage zubar da ciki da kuma zubar da ciki bayan lokaci. Haɗarin haihuwa da wuri.
4. Hana kumburi da hayaki ke haifarwa
Sakamakon binciken ya nuna cewa ƙungiyar da Farfesa Scott Budinger na Jami'ar Northwestern ya jagoranta ta tabbatar da cewa beraye na iya hana kumburi da hayaki ke haifarwa, hana ƙwayoyin rigakafi sakin wani ƙwayar cuta mai haɗari cikin jini, hana samuwar jijiyoyin jini, da kuma rage tsarin zuciya da jijiyoyin jini. Haɗarin kamuwa da cuta.
5. Kariyar zuciya da jijiyoyin jini
Metformin yana da tasirin kariya daga cututtukan zuciya da jijiyoyin jini kuma a halin yanzu ita ce kawai maganin da aka ba da shawarar a matsayin wanda ke da shaidar fa'idar cututtukan zuciya da jijiyoyin jini. Bincike ya nuna cewa maganin metformin na dogon lokaci yana da alaƙa da raguwar haɗarin cututtukan zuciya da jijiyoyin jini a cikin sabbin marasa lafiya da aka gano suna da ciwon suga na nau'in 2 da kuma marasa lafiya da ke da ciwon suga na nau'in 2 waɗanda suka riga sun kamu da cututtukan zuciya da jijiyoyin jini.
6. Inganta cutar polycystic ovary
Ciwon kwai na Polycystic wata cuta ce da ke da alaƙa da hyperandrogenemia, gazawar ovarian, da kuma yanayin polycystic ovary. Ba a fayyace ainihin cutar ba, kuma marasa lafiya galibi suna da matakai daban-daban na hyperinsulinemia. Bincike ya nuna cewa metformin na iya rage juriyar insulin, dawo da aikin ovulation, da kuma inganta hyperandrogenemia.
7. Inganta ƙwayoyin hanji
Bincike ya nuna cewa metformin na iya dawo da yawan ƙwayoyin hanji da kuma canza shi zuwa ga alkiblar da ta dace da lafiya. Yana samar da yanayi mai kyau ga ƙwayoyin cuta masu amfani a cikin hanji, ta haka yana rage sukari a cikin jini da kuma daidaita tsarin garkuwar jiki yadda ya kamata.
8. Ana sa ran zai magance wasu cututtukan Autism
Kwanan nan, masu bincike a Jami'ar McGill sun gano cewa metformin na iya magance wasu nau'ikan cututtukan Fragile X tare da autism, kuma an buga wannan sabon binciken a cikin mujallar Nature Medicine, wani ƙaramin fitowar Nature. A halin yanzu, autism yana ɗaya daga cikin cututtukan lafiya da yawa da masana kimiyya ke ganin za a iya magance su da metformin.
9. Juyawar fibrosis na huhu
Masu bincike a Jami'ar Alabama da ke Birmingham sun gano cewa a cikin marasa lafiya da ke fama da cutar fibrosis ta huhu da kuma nau'ikan fibrosis na huhu da bleomycin ke haifarwa, ayyukan AMPK a cikin kyallen fibrotic yana raguwa, kuma kyallen suna tsayayya da ƙwayoyin halitta. Ƙwayoyin myofibroblasts na apoptotic sun ƙaru.
Amfani da metformin don kunna AMPK a cikin myofibroblasts na iya sake farfaɗo da waɗannan ƙwayoyin zuwa apoptosis. Bugu da ƙari, a cikin samfurin linzamin kwamfuta, metformin na iya hanzarta cire ƙwayoyin fibrotic da aka riga aka samar. Wannan binciken ya nuna cewa ana iya amfani da metformin ko wasu agonists na AMPK don mayar da fibrosis da ya riga ya faru.
10. Taimaka wajen daina shan taba
Masu bincike a Jami'ar Pennsylvania sun gano cewa amfani da nicotine na dogon lokaci na iya haifar da kunna hanyar siginar AMPK, wanda ake hana shi yayin janye nicotine. Saboda haka, sun kammala da cewa idan aka yi amfani da magunguna don kunna hanyar siginar AMPK, yana iya rage martanin janyewa.
Metformin yana da illa ga AMPK. Lokacin da masu binciken suka bai wa beraye da suka daina shan nicotine metformin, sun gano cewa hakan ya rage musu janyewar beraye. Bincikensu ya nuna cewa ana iya amfani da metformin don taimakawa wajen daina shan taba.
11. Tasirin hana kumburi
A baya, binciken da aka yi kafin asibiti da na asibiti sun nuna cewa metformin ba wai kawai zai iya inganta kumburi na yau da kullun ba ta hanyar inganta sigogin rayuwa kamar su hyperglycemia, juriya ga insulin da dyslipidemia na atherosclerotic, har ma yana da tasirin hana kumburi kai tsaye.
Bincike ya nuna cewa metformin na iya hana kumburi, galibi ta hanyar hana sinadarin protein kinase (AMPK) ko kuma hana sinadarin nuclear transcription factor B (NFB) mai zaman kansa.
12. Matsalar fahimta ta baya
Masu bincike a Jami'ar Texas da ke Dallas sun ƙirƙiri samfurin linzamin kwamfuta wanda ke kwaikwayon raunin fahimta da ke da alaƙa da ciwo. Sun yi amfani da wannan samfurin don gwada ingancin magunguna da yawa.
Sakamakon gwaji ya nuna cewa maganin berayen da ke ɗauke da nauyin metformin 200 mg/kg na tsawon kwanaki 7 na iya magance matsalar fahimta da ciwo ke haifarwa gaba ɗaya.
Gabapentin, wanda ke maganin ciwon jijiyoyi da farfadiya, ba shi da irin wannan tasiri. Wannan yana nufin cewa ana iya amfani da metformin a matsayin tsohon magani don magance matsalar fahimta ga marasa lafiya da ke fama da ciwon jijiyoyi.
13. Hana ci gaban ƙari
Kwanaki da suka gabata, a cewar Singularity.com, masana daga Cibiyar Nazarin Cututtuka ta Turai sun gano cewa metformin da azumi na iya aiki tare don hana ci gaban ciwon daji na beraye.
Ta hanyar ƙarin bincike, an gano cewa metformin da azumi suna hana ci gaban ƙari ta hanyar hanyar PP2A-GSK3β-MCL-1. An buga binciken a kan Ciwon daji.
14. Zai iya hana lalacewar macular
Dr. Yu-Yen Chen daga Babban Asibitin Tsohon Soja na Taichung da ke Taiwan, China kwanan nan ya gano cewa yawan lalacewar macular degeneration (AMD) da ke da alaƙa da tsufa a cikin marasa lafiya da ke fama da ciwon suga na nau'in 2 da ke shan metformin ya yi ƙasa sosai. Wannan ya nuna cewa yayin da ake sarrafa ciwon suga, ayyukan hana kumburi da hana tsufa na metformin suna da tasirin kariya ga AMD.
15. Ko kuma zai iya magance matsalar asarar gashi
Tawagar Huang Jing, wani masanin kimiyya ɗan ƙasar Sin a Jami'ar California, Los Angeles, ta gano cewa magunguna kamar metformin da rapamycin na iya ƙarfafa gashin beraye a lokacin hutun su shiga matakin girma da kuma haɓaka girman gashi. An buga wani bincike mai alaƙa da wannan a cikin shahararren mujallar ilimi mai suna Cell Reports.
Bugu da ƙari, lokacin da masana kimiyya suka yi amfani da metformin don magance marasa lafiya da ke fama da cutar polycystic ovary syndrome a China da Indiya, sun kuma lura cewa metformin yana da alaƙa da raguwar asarar gashi.
16. Juyawar shekarun halitta
Kwanan nan, shafin yanar gizo na hukuma na mujallar kimiyya da fasaha ta duniya "Nature" ya buga wani labari mai ban mamaki. Rahotanni sun nuna cewa wani ƙaramin bincike na asibiti a California ya nuna a karon farko cewa yana yiwuwa a juya agogon halittar ɗan adam. A cikin shekarar da ta gabata, masu aikin sa kai tara masu lafiya sun sha cakuda hormone na girma da magungunan ciwon suga guda biyu, gami da metformin. An auna ta hanyar nazarin alamun da ke kan kwayar halittar mutum, shekarun halittarsa sun ragu da matsakaicin shekaru 2.5.
17. Maganin da aka haɗa zai iya magance ciwon nono mai nau'in ciwon nono mai nau'in ciwon nono sau uku.
Kwanaki kaɗan da suka gabata, wata ƙungiya ƙarƙashin jagorancin Dr. Marsha rich rosner na Jami'ar Chicago ta gano cewa haɗakar metformin da wani tsohon magani, heme (panhematin), na iya kai hari ga maganin ciwon nono mai ɗauke da cutar kansa mai kama da ciwon nono wanda ke barazana ga lafiyar mata.
Kuma akwai shaidar cewa wannan dabarar maganin na iya yin tasiri ga nau'ikan cututtukan daji daban-daban kamar ciwon huhu, ciwon koda, ciwon mahaifa, ciwon prostate da kuma cutar sankarar myeloid mai tsanani. An buga wani bincike mai alaƙa a cikin babban mujallar Nature.
18. Zai iya rage illolin glucocorticoids
Kwanan nan, "The Lancet-Diabetes and Endocrinology" ta buga wani bincike - sakamakon binciken ya nuna cewa a wani gwaji na asibiti na mataki na 2, metformin da ake amfani da shi ga marasa lafiya da cututtukan kumburi na yau da kullun na iya inganta lafiyar metabolism da rage maganin glucocorticoid.
Gwaje-gwaje sun nuna cewa metformin na iya aiki ta hanyar babban furotin na metabolism AMPK, kuma hanyar aiki ta saba wa glucocorticoids, kuma tana da yuwuwar magance illolin da yawan amfani da glucocorticoids ke haifarwa.
19. Ina fatan magance cutar sclerosis mai yawa
A baya, wata ƙungiyar bincike karkashin jagorancin Robin JM Franklin na Jami'ar Cambridge da almajirinsa Peter van Wijngaarden sun buga wani labari a cikin babban mujallar "Cell Stem Cells" cewa sun sami wani nau'in ƙwayoyin jijiyoyi na musamman waɗanda ke tsufa waɗanda za su iya murmurewa bayan an yi musu magani da metformin. Dangane da alamun da ke haɓaka bambance-bambance, yana sake bayyana kuzarin ƙuruciya kuma yana ƙara haɓaka sake farfaɗo da myelin na jijiya.
Wannan binciken yana nufin cewa ana sa ran amfani da metformin wajen magance cututtukan da ke da alaƙa da jijiyoyi marasa canzawa, kamar su sclerosis mai yawa.
Lokacin Saƙo: Afrilu-21-2021