1. Ana sa ran zai inganta haɗarin gazawar koda da mutuwa daga cututtukan koda
Kungiyar abubuwan da ke ciki ta WuXi AppTec Medical New Vision ta fitar da labarai cewa, wani bincike da aka yi a mutane 10,000 ya nuna cewa metformin na iya inganta hadarin gazawar koda da kuma mutuwa daga cututtukan koda.
Wani binciken da aka buga a cikin Ƙungiyar Ciwon sukari ta Amurka (ADA) mujallar "Cibiyar Ciwon sukari" (Cire ciwon sukari) ya nuna cewa magunguna da nazarin rayuwa na fiye da mutane 10,000 sun nuna cewa nau'in ciwon sukari na 2 da ke fama da ciwon koda (CKD) yana da alaƙa da Metformin. raguwa a cikin haɗarin mutuwa da cututtukan koda na ƙarshe (ESRD), kuma baya ƙara haɗarin lactic acidosis.
Ciwon koda na yau da kullun cuta ce ta kowa da kowa na ciwon sukari.Idan aka yi la’akari da cewa ana iya ba wa marasa lafiya da ke da ƙarancin ƙwayar koda metformin, ƙungiyar binciken ta bincika marasa lafiya 2704 a cikin kowane rukunin biyu da ke shan metformin kuma ba su ɗauki metformin ba.
Sakamakon ya nuna cewa idan aka kwatanta da waɗanda ba su ɗauki metformin ba, marasa lafiya waɗanda suka ɗauki metformin sun sami raguwar 35% a cikin haɗarin mutuwa duka da raguwar 33% cikin haɗarin ci gaba zuwa cututtukan koda na ƙarshe.Wadannan fa'idodin sun bayyana a hankali bayan kimanin shekaru 2.5 na shan metformin.
A cewar rahoton, a cikin 'yan shekarun nan, jagororin FDA na Amurka sun ba da shawarar a sassauta amfani da metformin a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 da ke fama da ciwon koda, amma a cikin marasa lafiya da ƙananan ƙwayar koda.Ga marasa lafiya masu matsakaici (mataki na 3B) da cututtukan koda mai tsanani, amfani da metformin har yanzu yana da rigima.
Dokta Katherine R. Tuttle, farfesa a Jami’ar Washington da ke Amirka, ta ce: “Sakamakon binciken yana da ban ƙarfafa.Ko da a cikin marasa lafiya da ciwon koda mai tsanani, haɗarin lactic acidosis ya ragu sosai.Ga marasa lafiya da ke da nau'in ciwon sukari na 2 da cututtukan koda na yau da kullun, metformin na iya zama ma'aunin rigakafin mutuwa da kuma Muhimmin magani don gazawar koda, amma tunda wannan nazari ne na baya-bayan nan da lura, dole ne a fassara sakamakon a hankali.
2. Mabambantan hanyoyin warkewa na maganin sihirin metformin
Ana iya cewa Metformin tsohon magani ne na gargajiya wanda ya daɗe.A cikin haɓakar binciken magungunan hypoglycemic, a cikin 1957, masanin kimiyya na Faransa Stern ya buga sakamakon bincikensa kuma ya ƙara tsantsa lilac wanda ke da aikin hypoglycemic a cikin wake.Alkali, mai suna metformin, Glucophage, wanda ke nufin mai cin sukari.
A cikin 1994, FDA ta Amurka ta amince da metformin bisa hukuma don amfani da nau'in ciwon sukari na 2.Metformin, a matsayin magani mai iko don kula da nau'in ciwon sukari na 2, an jera shi azaman maganin hypoglycemic na farko a cikin jagororin jiyya iri-iri a gida da waje.Yana da fa'idodin ingantaccen tasirin hypoglycemic, ƙarancin haɗarin hypoglycemia, da ƙarancin farashi.A halin yanzu shine maganin da aka fi amfani dashi Daya daga cikin nau'ikan magungunan hypoglycemic.
A matsayin magani da aka gwada lokaci, an kiyasta cewa akwai fiye da miliyan 120 masu amfani da metformin a duk duniya.
Tare da zurfafa bincike, ana ci gaba da faɗaɗa yuwuwar warkewar metformin.Baya ga sabbin binciken da aka yi, an kuma gano metformin yana da kusan tasirin 20.
1. Anti-tsufa sakamako
A halin yanzu, Hukumar Abinci da Magunguna ta Amurka ta amince da gwajin asibiti na "amfani da metformin don yaƙar tsufa".Dalilin da yasa masana kimiyya na kasashen waje ke amfani da metformin a matsayin dan takarar maganin tsufa na iya zama saboda metformin na iya kara yawan kwayoyin oxygen da aka saki a cikin sel.Fiye da duka, wannan yana da alama yana ƙara lafiyar jiki kuma yana tsawaita rayuwa.
2. Rage nauyi
Metformin wakili ne na hypoglycemic wanda zai iya rage kiba.Zai iya ƙara haɓakar insulin kuma ya rage haɗin mai.Ga yawancin masu son ciwon sukari nau'in 2, asarar nauyi kanta abu ne da ke da tasiri don daidaita yanayin sukarin jini.
Wani binciken da ƙungiyar masu bincike na Shirin Rigakafin Ciwon sukari na Amurka (DPP) ya nuna cewa a cikin tsawon shekaru 7-8 da ba a makance ba, marasa lafiya da suka karɓi maganin metformin sun rasa matsakaicin nauyin kilogiram 3.1.
3. Rage hadarin zubar ciki da haihuwa da wuri ga wasu mata masu juna biyu
Wani sabon bincike da aka buga a cikin The Lancet ya nuna cewa metformin na iya rage haɗarin zubar ciki da haihuwa da wuri a wasu mata masu juna biyu.
A cewar rahotanni, masana kimiyya daga Jami'ar Kimiyya da Fasaha ta Norwegian (NTNU) da Asibitin St. Olavs sun gudanar da wani bincike na kusan shekaru 20 kuma sun gano cewa marasa lafiya da polycystic ovary syndrome suna shan metformin a karshen watanni 3 na ciki na iya ragewa bayan. ajalinsa zubar da ciki da zubar da ciki.Hadarin haihuwa da wuri.
4. Hana kumburin da hayaki ke haifarwa
Sakamakon binciken ya nuna cewa tawagar da Farfesa Scott Budinger na Jami’ar Arewa maso Yamma ya jagoranta ta tabbatar a cikin berayen cewa metformin na iya hana kumburin da hayaki ke haifarwa, da hana kwayoyin garkuwar jiki sakin kwayar halitta mai hatsari a cikin jini, da hana samuwar thrombosis na arterial, kuma ta haka ne. rage tsarin zuciya da jijiyoyin jini.Hadarin cuta.
5. Kariyar zuciya
Metformin yana da tasirin kariya na zuciya da jijiyoyin jini kuma a halin yanzu shine kawai maganin hypoglycemic da jagororin masu ciwon sukari suka ba da shawarar don samun tabbataccen shaidar fa'idar zuciya.Nazarin ya nuna cewa dogon lokaci na maganin metformin yana da alaƙa da raguwar haɗarin cututtukan zuciya a cikin sabbin masu cutar da nau'in ciwon sukari na 2 da nau'in ciwon sukari na 2 waɗanda suka riga sun kamu da cututtukan zuciya.
6. Inganta ciwon ovary na polycystic
Polycystic ovary ciwo cuta ce da ta bambanta da hyperandrogenemia, rashin aiki na ovarian, da polycystic ovary morphology.Ba a san abin da ke haifar da cutar ba, kuma marasa lafiya galibi suna da digiri daban-daban na hyperinsulinemia.Nazarin ya nuna cewa metformin na iya rage juriya na insulin, dawo da aikin ovulation, da inganta hyperandrogenemia.
7. Inganta flora na hanji
Nazarin ya nuna cewa metformin na iya dawo da adadin flora na hanji kuma ya canza shi ta hanyar da ta dace da lafiya.Yana ba da yanayin rayuwa mai fa'ida ga ƙwayoyin cuta masu amfani a cikin hanji, don haka rage sukarin jini da kuma daidaita tsarin rigakafi.
8. Ana sa ran maganin wasu Autism
Kwanan nan, masu bincike a Jami'ar McGill sun gano cewa metformin na iya magance wasu nau'o'in cututtukan Fragile X tare da Autism, kuma an buga wannan sabon binciken a cikin Mujallar Nature Medicine, wani karamin batu na Nature.A halin yanzu, Autism na ɗaya daga cikin yanayin kiwon lafiya da yawa waɗanda masana kimiyya suka yi imanin za a iya bi da su tare da metformin.
9. Reverse pulmonary fibrosis
Masu bincike a Jami'ar Alabama a Birmingham sun gano cewa a cikin marasa lafiya da ke fama da fibrosis na huhu na huhu da nau'in fibrosis na huhu na linzamin kwamfuta wanda bleomycin ya haifar, aikin AMPK a cikin kyallen takarda ya ragu, kuma kyallen takarda suna tsayayya da sel Apoptotic myofibroblasts ya karu.
Yin amfani da metformin don kunna AMPK a cikin myofibroblasts na iya sake farfado da waɗannan sel zuwa apoptosis.Bugu da ƙari, a cikin ƙirar linzamin kwamfuta, metformin na iya hanzarta zubar da ƙwayar fibrotic da aka riga aka samar.Wannan binciken ya nuna cewa ana iya amfani da metformin ko wasu agonists na AMPK don juyar da fibrosis wanda ya riga ya faru.
10. Taimakawa wajen daina shan taba
Masu bincike a Jami'ar Pennsylvania sun gano cewa amfani da nicotine na dogon lokaci zai iya haifar da kunna hanyar siginar AMPK, wanda aka hana a lokacin cirewar nicotine.Don haka, sun yanke shawarar cewa idan ana amfani da kwayoyi don kunna hanyar siginar AMPK, yana iya rage martanin janyewa.
Metformin shine agonist AMPK.Lokacin da masu binciken suka ba da metformin ga berayen da ke cire nicotine, sun gano cewa ya sauƙaƙa cire berayen.Binciken su ya nuna cewa ana iya amfani da metformin don taimakawa barin shan taba.
11. Anti-mai kumburi sakamako
A baya can, binciken bincike na asibiti da na asibiti ya nuna cewa metformin ba kawai zai iya inganta ƙumburi na yau da kullun ba ta hanyar inganta sigogi na rayuwa kamar hyperglycemia, juriya na insulin da atherosclerotic dyslipidemia, amma kuma yana da tasirin anti-mai kumburi kai tsaye.
Nazarin ya nuna cewa metformin na iya hana kumburi, galibi ta hanyar AMP-activated protein kinase (AMPK) -dogara ko hanawa mai zaman kanta na B (NFB).
12. Juya rashin fahimta
Masu bincike a Jami'ar Texas a Dallas sun ƙirƙiri samfurin linzamin kwamfuta wanda ke kwaikwayon rashin lafiyar da ke da alaƙa da ciwo.Sun yi amfani da wannan samfurin don gwada ingancin magunguna da yawa.
Sakamakon gwaji ya nuna cewa maganin beraye tare da nauyin 200 MG / kg na metformin na tsawon kwanaki 7 na iya juyar da rashin lafiyar da ke haifar da ciwo.
Gabapentin, wanda ke magance neuralgia da farfadiya, ba shi da irin wannan tasiri.Wannan yana nufin cewa ana iya amfani da metformin azaman tsohuwar magani don magance rashin fahimta a cikin marasa lafiya da neuralgia.
13. Hana haɓakar ƙari
Bayan 'yan kwanaki da suka gabata, bisa ga Singularity.com, masana daga Cibiyar Nazarin Oncology ta Turai sun gano cewa metformin da azumi na iya yin aiki tare da juna don hana ci gaban ciwan linzamin kwamfuta.
Ta hanyar ƙarin bincike, an gano cewa metformin da azumi suna hana ci gaban ƙwayar cuta ta hanyar PP2A-GSK3β-MCL-1.An buga binciken ne akan kwayar cutar daji.
14. Zai iya hana macular degeneration
Dokta Yu-Yen Chen daga Babban Asibitin Tsohon Sojoji na Taichung da ke Taiwan a kasar Sin kwanan nan ya gano cewa, yawan kamuwa da cutar macular degeneration (AMD) da ke da alaka da shekaru a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 na shan metformin ya ragu sosai.Wannan yana nuna cewa yayin sarrafa ciwon sukari, ayyukan anti-inflammatory da antioxidant na metformin suna da tasirin kariya akan AMD.
15. Ko kuma yana iya magance zubar gashi
Tawagar Huang Jing, wani masanin kimiya na kasar Sin a jami'ar California dake Los Angeles, ya gano cewa, kwayoyi irin su metformin da rapamycin na iya kara kuzarin gashin da ke cikin lokacin hutun beraye don shiga lokacin girma da kuma kara habaka gashi.An buga bincike mai alaƙa a cikin shahararren mujallar ilimi ta Cell Reports.
Haka kuma, lokacin da masana kimiyya suka yi amfani da metformin don kula da marasa lafiya da ke fama da ciwon ovary na polycystic a China da Indiya, sun kuma lura cewa metformin yana da alaƙa da rage asarar gashi.
16. Juya shekarun ilimin halitta
Kwanan nan, gidan yanar gizon hukuma na mujallar kimiyya da fasaha ta kasa da kasa "Nature" ta buga wani labari mai ban tsoro.Rahotanni sun nuna cewa wani karamin bincike na asibiti a California ya nuna a karon farko cewa yana yiwuwa a juya agogon epigenetic na ɗan adam.A cikin shekarar da ta gabata, masu sa kai masu lafiya guda tara sun ɗauki cakuda hormone girma da magungunan ciwon sukari guda biyu, gami da metformin.Da aka auna ta hanyar nazarin alamomi akan kwayoyin halittar mutum, shekarun ilimin halittarsu ya ragu da matsakaicin shekaru 2.5.
17. Haɗin magani na iya magance cutar kansar nono mara kyau sau uku
Kwanakin baya, wata tawagar da Dr. Marsha rich rosner na Jami’ar Chicago ya jagoranta, ta gano cewa hadewar metformin da wani tsohon magani mai suna heme (panhematin), na iya kaiwa ga magance cutar kansar nono mai sau uku wanda ke matukar barazana ga lafiyar mata. .
Kuma akwai shaidar cewa wannan dabarar maganin na iya yin tasiri ga cututtukan daji iri-iri kamar su kansar huhu, ciwon koda, kansar mahaifa, ciwon gurguwar prostate da kuma cutar sankarar myeloid mai tsanani.An buga bincike mai alaƙa a cikin babban mujallar Nature.
18. Yana iya rage mummunan tasirin glucocorticoids
Kwanan nan, "Lancet-Diabetes da Endocrinology" sun buga wani binciken-sakamakon binciken ya nuna cewa a cikin gwajin gwaji na lokaci na 2, metformin da aka yi amfani da shi a cikin marasa lafiya da cututtukan cututtuka na yau da kullum na iya inganta lafiyar lafiyar jiki da kuma rage maganin glucocorticoid.
Gwaje-gwaje sun nuna cewa metformin na iya yin aiki ta hanyar mabuɗin furotin na rayuwa AMPK, kuma tsarin aikin shine kishiyar glucocorticoids, kuma yana da yuwuwar juyar da illolin da ke haifar da yawan amfani da glucocorticoids.
19. Fatan maganin sclerosis
A baya can, wata tawagar bincike karkashin jagorancin Robin JM Franklin na Jami'ar Cambridge da almajirinsa Peter van Wijngaarden sun buga wata kasida a cikin babbar mujalla mai suna "Cell Stem Cells" cewa sun sami wani nau'i na musamman na tsofaffin ƙwayoyin jikin jiki wanda zai iya farfadowa bayan jiyya tare da shi. metformin.Dangane da bambance-bambancen siginar haɓakawa, yana sake bayyana ƙarfin ƙuruciyar ƙuruciya kuma yana ƙara haɓaka haɓakar jijiyar myelin.
Wannan binciken yana nufin cewa ana sa ran za a yi amfani da metformin don magance cututtukan da ba za a iya jurewa ba, kamar sclerosis mai yawa.
Lokacin aikawa: Afrilu-21-2021